Zinc content in liver of experimental fulminant hepatic failure rat.

Glyphosate Poisoning with Acute Fulminant Hepatic Failure

Background: Glyphosate containing herbicides are widely used the world over. They are marketed as nontoxic to humans, but numerous studies have showed that these glyphosate-based herbicides (GlySH) can cause multiorgan damage.1 Recent reports of animal studies on rats have raised a doubt of liver damage after long term exposure to GlySH. Case Presentation: a young male had chronic exposure to G...

Function of trace metal in experimental fulminant hepatic failure--special reference to variation in zinc content in liver.

The authors prepared D-galactosamine (Gal) hepatic failure rats and hepatic failure dogs induced by hepatic ischemia and studied the correlation between the progress of hepatic failure and amount of trace metal in liver measured of the rats and dogs. After Gal was given, the rats rapidly fell into hepatic failure condition. They were sacrificed with the lapse of time and their zinc (Zn) content...

An animal model of fulminant hepatic failure in the rat.

A reproducible animal model of fulminant hepatic failure was developed by intraperitoneal administration of D-galactosamine hydrochloride to Sprague-Dawley rats. Biochemical and morphological hepatic injury and brain edema resembled human fulminant hepatic failure. This model would facilitate further studies of the pathogenesis of brain dysfunction and evaluation of treatment in fulminant hepat...

Acute fulminant hepatic failure due to colchicine – a rare manifestation of Gloriosa superba poisoning.

Chronic Zinc Oxide Nanoparticles Exposure Produces Hepatic and Pancreatic Impairment in Female Rats

Background: Zinc oxide (ZnO) nanoparticles are used for various industrial and domestic purposes and its release into the environment leads to the adverse effects among humans. This study aimed to evaluate the effect of rat exposure to ZnO nanoparticles on the histopathology of the liver and pancreas tissues, and serum oxidative stress parameters. Methods: Eighty female adult Wistar rats were ...